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Interferon gamma in cancer immunotherapy

Interferon gamma in cancer immunotherapy Immune system can recognize self vs transformed self. That is why cancer immunotherapy achieves notable benefits in a wide variety of cancers. Recently, several papers reported that immune checkpoint blockade therapy led to upregulation of IFNγ and in turn clearance of tumor cells. In this review, we conducted an extensive literature search of recent 5‐year studies about the roles of IFNγ signaling in both tumor immune surveillance and immune evasion. In addition to well‐known functions, [...]

INTRODUCTION TO NK ACTIVITY TEST

Decreased Natural killer cell activity (NKA) for interferon-gamma production (NKA-IFNγ) has been reported in cancer patients. The aim of this study was to determine the diagnostic performance of NKA-IFNγ for gastric cancer (GC). Results NKA-IFNγ levels were decreased in 261 GC patients with all stages of tumor compared to those in 48 healthy donors (P < 0.001), and lower levels of NKA-IFNγ were associated with higher GC stages. NKA-IFNγ levels were also associated with clinicopathological parameters including tumor size, [...]

Reduction of the CD16(-)CD56bright NK cell subset precedes NK cell dysfunction in prostate cancer

Background: Natural cytotoxicity, mediated by natural killer (NK) cells plays an important role in the inhibition and elimination of malignant tumor cells. To investigate the immunoregulatory role of NK cells and their potential as diagnostic markers, NK cell activity (NKA) was analyzed in prostate cancer (PCa) patients with particular focus on NK cell subset distribution. Methods: Prospective data of NKA and NK cell subset distribution patterns were measured from 51 patients initially diagnosed with PCa and 54 healthy controls. [...]

Harnessing NK Cells for Cancer Treatment

In the last years, natural killer (NK) cell-based immunotherapy has emerged as a promising therapeutic approach for solid tumors and hematological malignancies. NK cells are innate lymphocytes with an array of functional competences, including anti-cancer, anti-viral, and anti-graft-vs.-host disease potential. The intriguing idea of harnessing such potent innate immune system effectors for cancer treatment led to the development of clinical trials based on the adoptive therapy of NK cells or on the use of monoclonal antibodies targeting the main [...]

Natural killer cell activity for IFN-gamma production as a supportive diagnostic marker for gastric cancer

Background/Aim Decreased Natural killer cell activity (NKA) for interferon-gamma production (NKA-IFNγ) has been reported in cancer patients. The aim of this study was to determine the diagnostic performance of NKA-IFNγ for gastric cancer (GC). Results NKA-IFNγ levels were decreased in 261 GC patients with all stages of tumor compared to those in 48 healthy donors (P < 0.001), and lower levels of NKA-IFNγ were associated with higher GC stages. NKA-IFNγ levels were also associated with clinicopathological parameters including tumor size, depth of [...]

Test for Antinuclear Antibodies

What is ANA? ANA (antinuclear antibodies) is a term used to describe a diverse group of antibodies whose target is the nuclear antigen and cytoplasm of the cell. Thus, ANA is the specific autoantibodies produced by the body against one or more components of the patient’s own cell nucleus. ANA does not distinguish between foreign antigens and body tissue. So they attack the body’s cells causing signs and symptoms such as organ tissue inflammation, joint and muscle pain, fatigue … Prolonged [...]

Drug Allergy

Drug allergy is one of the undesirable effects of drug allergy, and is a rather difficult clinical problem. Medicines that cause allergies include many types, including: – Antibiotics – Anti-TB drugs Synthetic antithyroid drugs – Allopurinol (Uric acid-lowering drug, indicated in the prong and treatment of gout) – Carbamazepin – … By testing techniques, it is possible to partially predict the risk of drug allergy (when the patient has not used the drug) or identify the most likely drug to be the cause of allergy [...]

INTRODUCTION

1. INTRODUCTION In recent years, the development of technology in the Immunology has helped diagnose and treat many diseases that have not previously found the cause and / or have not been effectively treated. Among them, there are cancer, autoimmune diseases, infertility related to spontaneous miscarriage … The 2018 Nobel Prize in Medicine – awarded to a research on immunotherapy in cancer using immunosuppressants – is a clear demonstration of the specialist’s role and application. Immunology in Medicine today. Established at the [...]

Natural Killer Cells in Miscarriage

Killer cells & Pregnancy

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