Ung thư phổi

NK cell-based therapeutics for lung cancer

Abstract With the development of technologies that can transform immune cells into therapeutic modalities, immunotherapy has remarkably changed the current paradigm of cancer treatment in recent years. NK cells are components of the innate immune system that act as key regulators and exhibit a potent tumor cytolytic function. Unlike T cells, NK cells exhibit tumor cytotoxicity by recognizing non-self, without deliberate immunization or activation. Currently, researchers have developed various approaches to improve the number and anti-tumor function of NK cells. [...]

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Phẩu thuật

Prolonged Immunoparalysis of NK Cells After Surgery.

After surgery, immune system function is impaired, which has been acknowledged by surgeons. After cancer surgery, it was found that anti-cancer ability through direct poisoning mechanism of NK cells was reduced (transiently, about 1 week). The study found that in more than 90% of patients surveyed, NK cell Interferon gamma secretion activity decreased below detection levels of this assay, and this decrease persisted up to 1 month after surgery with about 65 % of cases. phau-thuat

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Interferon Alpha

Interferon gamma in cancer immunotherapy

Interferon gamma in cancer immunotherapy Immune system can recognize self vs transformed self. That is why cancer immunotherapy achieves notable benefits in a wide variety of cancers. Recently, several papers reported that immune checkpoint blockade therapy led to upregulation of IFNγ and in turn clearance of tumor cells. In this review, we conducted an extensive literature search of recent 5‐year studies about the roles of IFNγ signaling in both tumor immune surveillance and immune evasion. In addition to well‐known functions, [...]

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Xét nghiệm hoạt tính tế bào NK

INTRODUCTION TO NK ACTIVITY TEST

Decreased Natural killer cell activity (NKA) for interferon-gamma production (NKA-IFNγ) has been reported in cancer patients. The aim of this study was to determine the diagnostic performance of NKA-IFNγ for gastric cancer (GC). Results NKA-IFNγ levels were decreased in 261 GC patients with all stages of tumor compared to those in 48 healthy donors (P < 0.001), and lower levels of NKA-IFNγ were associated with higher GC stages. NKA-IFNγ levels were also associated with clinicopathological parameters including tumor size, [...]

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Tế bào miễn dịch

Reduction of the CD16(-)CD56bright NK cell subset precedes NK cell dysfunction in prostate cancer

Background: Natural cytotoxicity, mediated by natural killer (NK) cells plays an important role in the inhibition and elimination of malignant tumor cells. To investigate the immunoregulatory role of NK cells and their potential as diagnostic markers, NK cell activity (NKA) was analyzed in prostate cancer (PCa) patients with particular focus on NK cell subset distribution. Methods: Prospective data of NKA and NK cell subset distribution patterns were measured from 51 patients initially diagnosed with PCa and 54 healthy controls. [...]

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Tế bào tiêu diệt tự nhiên

Harnessing NK Cells for Cancer Treatment

In the last years, natural killer (NK) cell-based immunotherapy has emerged as a promising therapeutic approach for solid tumors and hematological malignancies. NK cells are innate lymphocytes with an array of functional competences, including anti-cancer, anti-viral, and anti-graft-vs.-host disease potential. The intriguing idea of harnessing such potent innate immune system effectors for cancer treatment led to the development of clinical trials based on the adoptive therapy of NK cells or on the use of monoclonal antibodies targeting the main [...]

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Natural killer cell activity for IFN-gamma production as a supportive diagnostic marker for gastric cancer

Background/Aim Decreased Natural killer cell activity (NKA) for interferon-gamma production (NKA-IFNγ) has been reported in cancer patients. The aim of this study was to determine the diagnostic performance of NKA-IFNγ for gastric cancer (GC). Results NKA-IFNγ levels were decreased in 261 GC patients with all stages of tumor compared to those in 48 healthy donors (P < 0.001), and lower levels of NKA-IFNγ were associated with higher GC stages. NKA-IFNγ levels were also associated with clinicopathological parameters including tumor size, depth of [...]

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Test for Antinuclear Antibodies

What is ANA? ANA (antinuclear antibodies) is a term used to describe a diverse group of antibodies whose target is the nuclear antigen and cytoplasm of the cell. Thus, ANA is the specific autoantibodies produced by the body against one or more components of the patient’s own cell nucleus. ANA does not distinguish between foreign antigens and body tissue. So they attack the body’s cells causing signs and symptoms such as organ tissue inflammation, joint and muscle pain, fatigue … Prolonged [...]

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Drug Allergy

Drug allergy is one of the undesirable effects of drug allergy, and is a rather difficult clinical problem. Medicines that cause allergies include many types, including: – Antibiotics – Anti-TB drugs Synthetic antithyroid drugs – Allopurinol (Uric acid-lowering drug, indicated in the prong and treatment of gout) – Carbamazepin – … By testing techniques, it is possible to partially predict the risk of drug allergy (when the patient has not used the drug) or identify the most likely drug to be the cause of allergy [...]

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FREQUENTLY ASKED QUESTIONS ON NATURAL KILLER CELL ACTIVITY TESTING IN OBSTETRICS

What is the role of NK cells in pregnancy? In the early stages of pregnancy, a large number of NK cells are found in the uterine lining (uNK), these NK cells play an active role in regulating the effect between immune cells. The fluid here is balanced, which helps the woman’s body “tolerate” the fetus. In other words, the relationship between the pregnant woman’s body and the embryo is harmonized and “in harmony”. On the other hand, the presence of NK [...]

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