Nk cell activity in cancer

NK cell-based therapeutics for lung cancer

Abstract With the development of technologies that can transform immune cells into therapeutic modalities, immunotherapy has remarkably changed the current paradigm of cancer treatment in recent years. NK cells are components of the innate immune system that act as key regulators and exhibit a potent tumor cytolytic function. Unlike T cells, NK cells exhibit tumor cytotoxicity by recognizing non-self, without deliberate immunization or activation. Currently, researchers have developed various approaches to improve the number and anti-tumor function of NK cells. [...]

Prolonged Immunoparalysis of NK Cells After Surgery.

After surgery, immune system function is impaired, which has been acknowledged by surgeons. After cancer surgery, it was found that anti-cancer ability through direct poisoning mechanism of NK cells was reduced (transiently, about 1 week). The study found that in more than 90% of patients surveyed, NK cell Interferon gamma secretion activity decreased below detection levels of this assay, and this decrease persisted up to 1 month after surgery with about 65 % of cases. phau-thuat

Interferon gamma in cancer immunotherapy

Interferon gamma in cancer immunotherapy Immune system can recognize self vs transformed self. That is why cancer immunotherapy achieves notable benefits in a wide variety of cancers. Recently, several papers reported that immune checkpoint blockade therapy led to upregulation of IFNγ and in turn clearance of tumor cells. In this review, we conducted an extensive literature search of recent 5‐year studies about the roles of IFNγ signaling in both tumor immune surveillance and immune evasion. In addition to well‐known functions, [...]

Reduction of the CD16(-)CD56bright NK cell subset precedes NK cell dysfunction in prostate cancer

Background: Natural cytotoxicity, mediated by natural killer (NK) cells plays an important role in the inhibition and elimination of malignant tumor cells. To investigate the immunoregulatory role of NK cells and their potential as diagnostic markers, NK cell activity (NKA) was analyzed in prostate cancer (PCa) patients with particular focus on NK cell subset distribution. Methods: Prospective data of NKA and NK cell subset distribution patterns were measured from 51 patients initially diagnosed with PCa and 54 healthy controls. [...]

Harnessing NK Cells for Cancer Treatment

In the last years, natural killer (NK) cell-based immunotherapy has emerged as a promising therapeutic approach for solid tumors and hematological malignancies. NK cells are innate lymphocytes with an array of functional competences, including anti-cancer, anti-viral, and anti-graft-vs.-host disease potential. The intriguing idea of harnessing such potent innate immune system effectors for cancer treatment led to the development of clinical trials based on the adoptive therapy of NK cells or on the use of monoclonal antibodies targeting the main [...]

Natural killer cell activity for IFN-gamma production as a supportive diagnostic marker for gastric cancer

Background/Aim Decreased Natural killer cell activity (NKA) for interferon-gamma production (NKA-IFNγ) has been reported in cancer patients. The aim of this study was to determine the diagnostic performance of NKA-IFNγ for gastric cancer (GC). Results NKA-IFNγ levels were decreased in 261 GC patients with all stages of tumor compared to those in 48 healthy donors (P < 0.001), and lower levels of NKA-IFNγ were associated with higher GC stages. NKA-IFNγ levels were also associated with clinicopathological parameters including tumor size, depth of [...]

NK CELL ACTIVITY IN CANCER

NK Vue ™ test kit Meaning NK cell activity evaluation has been shown to be a useful tool for monitoring changes in (immunosurveillance). From there, NK activity can indicate signs of an underlying medical condition or an existing condition in the body tested. NK Vue™ (Researched and developed by ATGen Co., Korea, 2013) is a non-invasive test and intervention in patients, just 1 ml of blood is cultured in specialized environment to evaluate ability to secrete and eliminate foreign cells of [...]